发明名称 |
BINDING OF OSTEOGENIC PROTEIN-I (OP-1) AND ANALOGS THEREOF TO THE CELL SURFACE RECEPTOR ALK-1 AND ANALOGS THEREOF |
摘要 |
Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features, and various other data characterizing morphogen cell surface receptors, particularly OP-1-binding cell surface receptors, e.g., ALK-1; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying and producing morphogen analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic, and experimental uses. |
申请公布号 |
WO9707135(A3) |
申请公布日期 |
1997.05.22 |
申请号 |
WO1996US13163 |
申请日期 |
1996.08.13 |
申请人 |
CREATIVE BIOMOLECULES, INC.;THE LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
ICHIJO, HIDENORI;NISHITOH, HIDEKI;SAMPATH, KUBER, T. |
分类号 |
G01N33/566;A61K38/00;A61K45/00;A61P43/00;C07K14/51;C07K14/71;C07K16/18;C12N15/09;C12P21/02;C12Q1/02 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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