发明名称 |
NIMA INTERACTING PROTEINS |
摘要 |
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.
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申请公布号 |
WO9717986(A1) |
申请公布日期 |
1997.05.22 |
申请号 |
WO1996US17334 |
申请日期 |
1996.10.28 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
HUNTER, TONY;LU, KUN, PING |
分类号 |
A61K38/00;C12N9/90;(IPC1-7):A61K38/16;A61K31/00;C07K16/00;C12P21/08;C07H21/02;C07H21/04;C12N15/00;C12N5/00;C12N1/20;C12N1/14;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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