发明名称 |
Formation and use of prion protein (prp) complexes |
摘要 |
Prion protein (PrP) peptides having at least one alpha -helical domain and forming a random coil conformation in aqueous solutions bind cellular PrP (PrPC) to form a complex having characteristics of the scrapie isoform (PrPSc). Methods for screening compounds able to inhibit or decrease the binding of PrP peptides to PrPC are disclosed, as well as methods for assaying PrPSc. |
申请公布号 |
AU7601296(A) |
申请公布日期 |
1997.05.22 |
申请号 |
AU19960076012 |
申请日期 |
1996.10.28 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
STANLEY B PRUSINER;KIYOTOSHI KANEKO;FRED E. COHEN |
分类号 |
G01N33/53;C07K14/47;C07K16/18;C12N15/09;G01N33/566;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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