发明名称 |
SEPARATION OF MOLECULES FROM DILUTE SOLUTIONS USING COMPOSITE CHROMATOGRAPHY MEDIA HAVING HIGH DYNAMIC SORPTIVE CAPACITY AT HIGH FLOW RATES |
摘要 |
This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.
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申请公布号 |
WO9718024(A1) |
申请公布日期 |
1997.05.22 |
申请号 |
WO1996US17345 |
申请日期 |
1996.10.30 |
申请人 |
BIOSEPRA, INC. |
发明人 |
COFFMAN, JONATHAN, L.;GIROT, PIERRE;BOSCHETTI, EGISTO |
分类号 |
B01D15/08;C07K1/18;(IPC1-7):B01D15/08 |
主分类号 |
B01D15/08 |
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