A METHOD AND APPARATUS FOR PRODUCING LIPOSOMAL PARENTERAL MEDICAMENTS VIA HIGH PRESSURE HOMOGENIZATION

摘要

According to the proposed method of producing a parenterally administered medicament formulation, a liposome dispersion is used as a carrier for a pharmaceutically active substance. To produce the liposome dispersion, an aqueous pre-dispersion of one or more amphiphilic substances is fed into a high-pressure homogeniser in which it is pumped at a pressure of 600 to 900 bar through a homogeniser nozzle with a diameter of 0.1 to 0.5 mm. The homogeniser nozzle has a feed channel and a discharge channel and comprises a hard ceramic plate in which the bore is located and which is pressed into a steel unit. The feed channel and discharge channel are likewise assimilated into the steel unit.