Adenovirus-antisense k-ras expression vectors and their application in cancer therapy

摘要

A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, adenoviral expression vectors are provided that contain a K-ras nucleic acid positioned antisense to regulatory control regions. In one embodiment, the adenoviral expression vector is a replication-deficient adenoviral vector lacking the E1 region and containing a K-ras nucleic acid. Also provided are methods for the inhibition of cancer cell proliferation.