Pollenosis-inducing polypeptide, process for preparing the same, and uses thereof

摘要

A polypeptide having a molecular weight of 40,000+/-5,000 daltons and an isoelectric point of 9.5+/-0.5 is prepared from a cedar pollen. The polypeptide which induces pollenosis can be suitably used as desensitization agent because it induces immunoglobulin antibody which is effective for desensitization, but does not substantially induce immunoglobulin E antibody, a major factor causative of side effects including anaphylaxis shock. Therefore, the polypeptide can be advantageously used in the treatment, prevention and/or diagnosis of pollenosis.