Spicamycin derivatives and the use thereof

摘要

Disclosed is a novel spicamycin derivative represented by the formula (I) or a salt thereof: <IMAGE> (I) wherein R represents an alkenyl having a given number of carbon atoms, a haloalkyl having a given number of carbon atoms, CH3(CH2)nCH(OH)- or CH3(CH2)n-1CH(OH)-CH2- (wherein n denotes an integer of 9-13), an alkyl with a certain group and a given number of carbon atoms, <IMAGE> <IMAGE> <IMAGE> (wherein a denotes 2, and b denotes an integer of 10-15), CH3(CH2)cSO2O(CH2)d-, <IMAGE> (wherein c denotes an integer of 0-3 and d denotes an integer of 10-15), (CH3)3Si(CH2)10-, (CH3)3Si-C 3BOND C-(CH2)8-, <IMAGE> <IMAGE> or <IMAGE> (wherein X represents O or S), and R1 and R2 are different from each other and each represents H or OH, which exhibits an excellent antitumor effect and has a high therapeutic index. An antitumor agent containing at least one of the above-described compounds in an effective amount is also disclosed.