| 摘要 |
<p>The present invention provides an excellent composition for improving pancreatic function, the composition for promoting differentiation of undifferentiated pancreatic stem cells to pancreatic beta cells and the composition for preventing or treating undifferentiated type of pancreatic cancer, which comprises a BTC protein or a mutein thereof. The composition of the present invention acts on undifferentiated pancreatic stem cells to promote their differentiation to insulin-producing pancreatic beta cells. It also has an activity for induction of differentiation of undifferentiated pancreatic stem cells to other pancreatic cells such as F cells which produce pancreatic peptides. The composition of the present invention is therefore capable of promoting mitigation and healing of diabetes mellitus (e.g., insulin-dependent diabetes mellitus), pancreatic dysfunction in diabetes mellitus etc., and improves pancreatic function. And, the composition of the present invention is also useful as a composition for preventing or treating undifferentiated type of pancreatic cancer.</p> |
