摘要 |
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
|
申请人 |
SMITHKLINE BEECHAM CORPORATION;CLARK, WILLIAM, MORROW;LANTOS, IVAN;MILLS, ROBERT, JOHN;PRIDGEN, ROBERT, JOHN;TICKNER, ANN, MARIE |
发明人 |
CLARK, WILLIAM, MORROW;LANTOS, IVAN;MILLS, ROBERT, JOHN;PRIDGEN, ROBERT, JOHN;TICKNER, ANN, MARIE |