DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS

摘要

Derivatives of N,N-dimethyl-2-(arylthio)benzylamine of general formula (I), wherein the substituents R1 and R2 in the A ring in the 4 and 5 positions are hydrogen, fluorine, or chlorine atoms, while at least one of them must be a hydrogen atom and further, among the substituents R<3> to R<6> in the B ring two to three are hydrogen atoms, another one is either one fluorine or chlorine atom (only if at least one of the substituents R1 to R2 in the A ring is a fluorine or chlorine atom), further, two fluorine or two chlorine atoms, an alkyl with one to three carbon atoms, trifluoromethyl, methylthio, methylsulfinyl, methoxyl or hydroxyl (only if in the B ring there is also a fluorine or chlorine atoms as a substituent), nitro, amino, hydroxymethyl - except the 2 position, carboxyl - except the 3 position, methoxycarbonyl or ethoxycarbonyl group, as well as their salts with pharmacodynamically harmless acids. Methods of preparation of these compounds have been described, as well as some of their pharmacological characteristics and ways of their use in pharmaceutical medicaments based on their ability to selectively influence serotonin transport in the central nervous system.