发明名称 |
Chimeric receptor genes and cells transformed therewith |
摘要 |
Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods. |
申请公布号 |
AU7472496(A) |
申请公布日期 |
1997.05.15 |
申请号 |
AU19960074724 |
申请日期 |
1996.10.24 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED B |
发明人 |
STEVEN A ROSENBERG;PATRICK HWU;ZELIG ESHHAR;DANIEL SCHINDLER;TOVA WAKS;GIDEON GROSS |
分类号 |
A61K35/14;A61K38/00;C07K14/715;C07K14/725;C07K14/735;C07K16/10;C07K16/30;C07K16/32;C07K16/42;C07K16/44;C12N15/13 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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