发明名称 |
A PROCESS OF MAKING 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIC ACID DERIVATIVES |
摘要 |
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-¢2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl!-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
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申请公布号 |
CA2236926(A1) |
申请公布日期 |
1997.05.15 |
申请号 |
CA19962236926 |
申请日期 |
1996.11.08 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
PRIDGEN, LENDON NORWOOD;LANTOS, IVAN;MILLS, ROBERT JOHN;TICKNER, ANN MARIE;CLARK, WILLIAM MORROW |
分类号 |
C07C49/84;C07C305/26;C07C309/65;C07D213/50;C07D317/50;C07D317/60;C07D405/04;C07F5/02;(IPC1-7):C07D317/60 |
主分类号 |
C07C49/84 |
代理机构 |
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