DNA encoding human alpha 1 adrenergic receptors and uses thereof

摘要

This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1B adrenergic receptor genes. This invention also provides a protein, antibody directed to the protein and pharmaceutical compounds related to alpha 1B adrenergic receptors. This invention provides nucleic acid probe, antisense oligonucleotide complementary to alpha 1B adrenergic receptor genes. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human alpha 1B adrenergic receptors.