New (hydroximino-alkylidene)-imino-oxymethyl-phenyl:acetic acid derivs.

摘要

alpha -(Methoximino, methoxymethylene or ethylidene)-2-(oximinoalkylideneaminooxymethyl)-phenylacetic acid derivs. of formula (I) and their salts are new. X = NOMe, CHOMe or CHMe; Y = NR or O; R, R1 = H or 1-4C alkyl; R2 = H, alkyl, 1-4C haloalkyl or cycloalkyl; R3 = (i) 4-6C cycloalkyl; (ii) 2-6C alkyl; or (iii) alkyl, alkynyl or alkenyl, (all partially or completely halogenated and/or substd. by 1-3 of CN, NO2, OH, SH, NH2, COOH, CONH2, CSNH2, halo, mono- or dialkylaminocarbonyl, mono- or dialkylaminothiocarbonyl, alkylsulphonyl, alkylsulphoxyl, alkoxy, haloalkoxy, alkoxycarbonyl, alkylthio, mono- or dialkylamino, alkenyloxy, cycloalkyl, cycloalkoxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy, aryl(1-4C)alkoxy, arylthio, aryl(1-4C)alkylthio, heteroaryl, heteroaryloxy, heteroaryl(1-4C)alkoxy, heteroarylthio and heteroaryl(1-4C)alkylthio (where the cyclic gps. are themselves opt. partially or completely halogenated and/or substd. by 1-3 of CN, NO2, OH, SH, NH2, COOH, CONH2, CSNH2, alkyl, haloalkyl, alkylsulphonyl, alkylsulphoxyl, cycloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, alkylthio, mono- or dialkylamino, mono- or dialkylaminocarbonyl, mono- or dialkylaminothiocarbonyl, alkenyl, alkenyloxy, benzyl, benzyloxy, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio and C(=NORa)-An-Rb)); R4 = (i) H; (ii) 1-10C alkyl, cycloalkyl, 2-10C alkenyl, 2-10C alkynyl, (1-10C)alkylcarbonyl, (2-10C)alkenylcarbonyl, 3-10C alkynylcarbonyl or 1-10C alkylsulphonyl, all opt. halogenated and/or substd. as for alkyl in R3, or (iii) aryl, arylcarbonyl, arylsulphonyl, heteroaryl, heteroarylcarbonyl or heteroarylsulphonyl (all opt. halogenated and/or substd. as for the cyclic gps. in R3); A = O, S , NH or N(alkyl); n = 0 or 1; Ra, Rb = H or alkyl; alkyl and alkoxy have 1-6C, alkenyl and alkynyl 2-6C and cycloalkyl has 3-6C unless specified otherwise; excluded are cpds. where (a) R1, R2 = Me, R3 = Et, R4 = Me or Et, X = NOMe and Y = NH or O; or (b) R3 = t-Bu.