发明名称 |
STABLE BIOTINYLATED BIOMOLECULE COMPOSITION AND METHODS |
摘要 |
Compositions and methods for biotinylated biomolecules, such as enzymes, are disclosed. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g., as a lyophilized powder cake. They have applicability in any case wherein avidin/biotin technology is used, and are particularly important as compositions containing a thrombin-like enzyme. The preparation of a fibrin monomer and fibrin monomer-based fibrin sealants are an example wherein avidin/biotin technology is used and methods of providing such monomers are also disclosed.
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申请公布号 |
WO9717435(A1) |
申请公布日期 |
1997.05.15 |
申请号 |
WO1996US17200 |
申请日期 |
1996.10.24 |
申请人 |
E.R. SQUIBB & SONS, INC. |
发明人 |
BURTON, STEVEN, J.;PEARSON, JAMES, C.;EDWARDSON, PETER, A., D.;MENZIES, ALAN |
分类号 |
G01N33/53;A61L2/00;C07D495/04;C07K14/75;C07K17/06;C12N9/00;C12N11/06;C12P21/00;G01N33/531;G01N33/543;(IPC1-7):C12N11/00;C12N11/02;C12N11/16;C12P21/06 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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