Use of N-substituted nicotinamide compounds for the treatment of acute and chronic inflammatory diseases

摘要

The use of a compound of the formula I <CHEM> or a pharmaceutically acceptable acid addition salt thereof, wherein R<3> is 1-piperidyl, 1-(3-indolyl)ethyl, (C1-C4)-alkyl, phenyl, benzyl, 1-(1-phenylethyl) or monosubstituted benzyl wherein the substituent is chloro, fluoro, methyl or methoxy and said substituent is on the aromatic ring; R<4> is bicycloÄ2.2.1Ühept-2-yl or a group of the formula II <CHEM> wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, methylcarbamoyl, dimethyl-carbamoyl or carbo(C1-C4)alkoxy; for the manufacture of a medicament for inhibiting phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF).