Chimeric animal and method for producing the same

摘要

Chimeric non-human animals retaining foreign chromosomes or fragments thereof and expressing the genes on the foreign chromosomes or fragments, and their progenies; a method for producing the chimeric non-human animals; tissues and cells derived from the chimeric non-human animals and their progenies; hybridomas prepared by fusion of said cells with myeloma cells; pluripotent cells containing foreign chromosomes or fragments thereof; a method for producing the pluripotent cells; use of the pluripotent cells for producing chimeric non-human animals; and a method for producing a biologically active substance, which comprises expressing the gene on a foreign chromosome or a fragment in the chimeric non-human animal or its progeny, or a tissue or a cell thereof, and recovering the biologically active substance as the expression product.