| 摘要 |
PROBLEM TO BE SOLVED: To obtain a medicinal composition for treating susurrus aurium which contains a specific nerve-protecting agent as an active ingredient and can cure, relieve and prevent mammalian susurrus aurium. SOLUTION: This susurrus aurium treatment uses a compound of formula I [when R<2> and R<5> are different groups from each other, R<1> -R<4> are independently H, a 1-6C alkyl, a halo, trifluoromethyl; R<5> is methyl; when R<2> and R<5> are incorporated to form a group of formula II forming chroman-4-ol ring, R<1> , R<3> and R<4> are independently H, a 1-6C alkyl, and a halo; R<6> is a group of formula III (R<8> is a 1-6C alkyl) or its pharmaceutically permissible salt as an active ingredient. (1S, 2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenyliperi-dinl-yl)-1- propanol, its tartaric salt, methane sulfonate salt or methane sulfonic trihydrate are particularly preferred. |
