CHIRAL BICYCLOPHOSPHORAMIDE COMPOUND AND PRODUCTION THEREOF, ASYMMETRIC CATALYST COMPRISING CHIRAL BICYCLOPHOSPHORAMIDE COMPOUND AND ASYMMETRIC SYNTHESIS

摘要

PROBLEM TO BE SOLVED: To obtain a new chiral bicyclophosphorylamide compound capable of holding the anti/syn selectivity of a product at a high level and greatly improving the asymmetric yield of the product on the asymmetric synthesis of the compound as useful as an intermediate for medicines, agricultural chemicals, etc. SOLUTION: The compound of formula I or II R<1> is a 1-5C alkyl, (substituted) benzyl, (substituted) phenetyl, (substituted) phenyl, (substituted) α-naphthyl; R<2> , R<3> are combined to each other to form a group of the formula: -(CH2 )n - [(n) is 4, 5] or combined to each other together with N to form a ring}. For example, a compound of formula III. The compound of formula I or II is obtained by reacting a pyrrolidine compound of formula IV with a phosphoramide compound of formula V (X is a halogen).