| 摘要 |
PROBLEM TO BE SOLVED: To provide the above compound having accumulation property to cancer cell, reactivity to external energy and destructing action on cancer cell, free from toxicity to normal cells and useful as an agent for the treatment or the diagnosis of cancer. SOLUTION: This porphyrin compound is expressed by the formula [R1 is CH3 , C2 H5 , CH2 CH(CH3 )2 , CH2 C6 H5 or CH2 C6 F5 ; R2 is a residue produced by removing H from aspartic acid) (including position isomers obtained by exchanging the functional groups of the side chains on the rings A and B among four tetrapyrrole rings in the formula), e.g. 13, 17-bispropionylaspartic acid-3- ethenyl-7-hydroxy-8-methoxyiminoethylidene-2,7,12,18-tetramethyl-porph yrin. The compound of the formula can be produced, e.g. by producing a chlorin derivative having corresponding aldehyde group, bonding an aspartic acid residue to the derivative and condensing the product to a hydroxylamine derivative. |
