| 摘要 |
PROBLEM TO BE SOLVED: To obtain an optically active compound mixture which comprises a specific optically active amino alcohol and an optically active amino alcohol ester having the reverse configuration to the former and is useful as an optical resolution agent or a chiral auxiliary for synthesizing optically active medicines and agrochemicals. SOLUTION: This optically active compound mixture comprises (A) an optically active isomer of a compound (A') of the formula I (X and Y are each a (substituted) alkyl, an aryl; X and Y may incorporate to form a (substituted) alkylene or an alkylene containing hetero atoms; n is 3-6) and (B) a compound which is) a compound (B') of formula II (Z is an acyl) and has the reverse optically active configuration as that of the component A. For example, the objective mixture is prepared by allowing a microorganism in Pseudomonas, Alcaligenes, Mucol, Phizopus, Aspergillus, or Phycomycetes, or a biochemical catalyst originating from these microorganisms to act on a dl-isomer of compound A' or B' in the presence of an acyl donor or an acyl acceptor thereby effecting asymmetric esterification or asymmetric deacylation. |
