发明名称 |
Adenosine as a positive inotrop in the compromised heart |
摘要 |
Disclosed are methods of increasing the contractile performance of a compromised myocardium in a mammal. The methods include administering a therapeutically affective amount of an adenosine A2 receptor agonist. Also disclosed are methods that include administering in conjunction with an adenosine A2 receptor agonist a second compound which potentiates the beneficial effect of the adenosine A2 receptor agonist, e.g., an adenosine transport inhibitor, an inhibitor of adenosine metabolism or an adenosine A1 receptor antagonist.
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申请公布号 |
US5629298(A) |
申请公布日期 |
1997.05.13 |
申请号 |
US19950402884 |
申请日期 |
1995.03.13 |
申请人 |
UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER |
发明人 |
DOBSON, JR., JAMES G. |
分类号 |
C07D473/06;A61K31/505;A61K31/52;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7076;A61K31/708;A61K45/00;A61P9/00;C07D473/08;C07D473/10;C07D473/34;C07H19/14;C07H19/16;C07H19/167;(IPC1-7):C07H19/16 |
主分类号 |
C07D473/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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