| 摘要 |
<p>A method of identifying an individual with a squamous intraepithelial lesion is disclosed. The method comprises the step of immunocytochemically analyzing samples of exfoliated cervical cells from an individual. The sample is air dried or desiccated by a non-immunologically neutralizing fixative and contacted with detectable antibodies that bind to antigens that are expressed by proliferating epithelial cells. After incubating the antibodies with the sample and then removing unbound antibodies, the sample inspected to detect the presence of antibodies bound to antigen in epithelial cells which indicates a squamous intraepithelial lesion in the sample. The present invention provides a method of identifying an individual with a squamous intraepithelial lesion by performing immunocytochemical analysis in parallel with Pap smear analysis or following identification of individuals with atypical squamous cells of undetermined significance by Pap smear analysis.</p> |
