STRUCTURE BASED DESIGN OF INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE

摘要

The present invention pertains to a method for designing inhibitors of enzyme human immunodeficiency virus type 1 reverse transcriptase which comprises the steps of: (a) providing a three-dimensional model of the receptor site in the prepolymerization complex of the p66 subunit of enzyme human immunodeficiency virus type 1 reverse transcriptase and a known nonnucleoside inhibitor; (b) locating the conserved residues in the p66 subunit which constitute the nonnucleoside inhibitor binding pocket; and (c) designing a new nonnucleoside inhibitor which possesses complementary structural features and binding forces to the residues in the p66 subunit nonnucleoside inhibitor binding pocket.