INHIBITION OF AMYLOIDOSIS BY 9-ACRIDINONES

摘要

Amyloid aggregation in animals is inhibited by administering a 9-acridinone compound of formula (I), wherein R<1> and R<2> are hydrogen, halo, nitro, amino, hydroxy, trifluoromethyl, alkyl, alkoxy, and alkylthio; R<3> is hydrogen or alkyl; and R<4> is -alkylene-NR<5>R<6>. The compounds are especially useful in preventing and treating Alzheimer's disease.