CULTUREWARE FOR BIOARTIFICIAL LIVER

摘要

A disposable cultureware (i.e., bioreactor support module (11) and tube set (12)) assembly (10) for use with a bioartificial liver employing a hollow fiber bioreactor (24 and 26) having an extracapillary flow path connected to both a culture (media) circuit (14) and a hemoperfusion (blood) circuit (16). The assembly (10) includes a gas exchange cartridge (20) operably connected to both the culture (14) and hemoperfusion (16) circuits for controllably gassing the media and blood prior to delivery to the bioreactor (24 and 26). The use of a single gas exchange cartridge (20) within both the media (14) and blood (16) circuits provides advantages in terms of both function and performance as compared to alternative approaches.