| 摘要 |
<p>A novel method for preparing substituted anthraquinones of general formula (I), wherein R is hydrogen atom or a straight or branched C1-5 alkyl group, a chloromethyl group, a -COCl group, a -COOR' group or a -CH2OR' group where R' is a hydrogen atom or a straight or branched C1-5 alkyl group, R1 is a hydrogen atom, a hydroxyl, straight or branched C1-5 alkoxy or C1-5 acyloxy group, and R2 is a hydrogen atom or a straight or branched C1-5 alkyl group, by means of a Diels-Alder reaction between a 1,4-naphthoquinone of general formula (II), wherein R1 has the meaning given above, and X is a hydrogen or halogen atom, and an acyclic diene of formula (III): CH2 = CR - CH = CH - OR3, wherein R has the meaning given above, and R3 is a straight or branched C1-5 alkyl group or an acyl group in which the alkyl portion is straight or branched and comprises 1-5 carbon atoms, followed by a saponification, aromatisation and oxidation reaction, to give a substituted anthraquinone of general formula (I). The method is suitable for preparing pharmaceutically useful rheins.</p> |
