| 摘要 |
PCT No. PCT/EP96/03605 Sec. 371 Date Jul. 31, 1997 Sec. 102(e) Date Jul. 31, 1997 PCT Filed Aug. 14, 1996 PCT Pub. No. WO97/14719 PCT Pub. Date Apr. 24, 1997A bispecific or bivalent double head antibody fragment, which is composed of a binding complex containing two polypeptide chains, whereby one polypeptide chain has two times a variable domain of a heavy chain (VH) in series and the other polypeptide chain has two times a variable domain of a light chain (VL) in series, and the binding complex contains two pairs of variable domains (VH-A//VL-A and VH-B//VL-B), wherein said double head antibody fragments have binfunctional antigen binding activity. A process for producing such an antibody fragment is disclosed. An immunoassay is also provided for, wherein the improvement is the inclusion of a bispecific or bivalent double head antibody fragment, which is composed of a binding complex containing two polypeptide chains, whereby one polypeptide chain has two times a variable domain of a heavy chain (VH) in series and the other polypeptide chain has two times a variable domain of a light chain (VL) in series, as a binding means. |
