| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel compound which has phosphodiesterase inhibitory action and is useful as a medicinal component. SOLUTION: A physiologically active substance NF00233A or its salt and has the following descriptions: appearance: a yellow powder, molecular weight: 614, molecular formula: C33 H58 O8 S, solubility: soluble in lower alcohol, insoluble in hexane, petroleum ether and water, Rf value of 0.4 in silica get thin layer chromatography with an eluent of chloroform/methanol (5:1), color reactions: positive to vanillin-sulfuric acid and to iodine. This compound is obtained by culturing a microorganism in Chaetomella capable of producing a physiologically active substance, NF00233A, such as Chaetomella raphigera NF00233 (FERMP-15190) and accumulating the substance in the medium. It is useful as a component of the following agents of antiasthmatic, bronchodilator, bronchitis remedy, antiallergic, anti-inflammatory, anti-rheumatic, hypotensor, angina pectoris remedy, antiarrhythmic, cerebral ameliorator, anticoagulant and antidepressant. |
