发明名称 |
Bone-related sulfatase-like protein and process for its production |
摘要 |
A bone-related protein named OSF-8 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of sulfatases. OSF-8 degrades the sulfate groups of the sugar chains of proteoglycan, which makes up the cartilage matrix, during the replacement of cartilage into bone tissue at the stage of osteogenesis. OSF-8 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
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申请公布号 |
US5627050(A) |
申请公布日期 |
1997.05.06 |
申请号 |
US19950445586 |
申请日期 |
1995.05.22 |
申请人 |
HOECHST JAPAN LIMITED |
发明人 |
TAKESHITA, SUNAO;ITO, TOSHIMI;OTAWARA-HAMAMOTO, YOKO;AMANN, EGON |
分类号 |
A61K36/06;A61K35/74;A61K38/00;A61K39/395;A61K49/00;A61P3/00;A61P43/00;C12N9/16;C12N15/55;C12P21/08;G01N33/53;(IPC1-7):C12P21/02 |
主分类号 |
A61K36/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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