A novel ligand (Efl-6) that binds the Elk subfamily of Eph receptors is identified, and methods for making the soluble Elf-6 ligand in biologically active form is described. A cDNA clone encoding this novel protein enables production of the recombinant protein, which is useful to support neuronal and other Eph receptor-bearing cell populations.
申请公布号
WO9715667(A1)
申请公布日期
1997.05.01
申请号
WO1996US17201
申请日期
1996.10.25
申请人
REGENERON PHARMACEUTICALS, INC.;DAVIS, SAMUEL;GALE, NICHOLAS, W.;YANCOPOULOS, GEORGE, D.
发明人
DAVIS, SAMUEL;GALE, NICHOLAS, W.;YANCOPOULOS, GEORGE, D.