The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5 alpha -reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5 alpha -reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.
申请公布号
WO9715305(A1)
申请公布日期
1997.05.01
申请号
WO1996US16871
申请日期
1996.10.22
申请人
MERCK & CO., INC.;BULL, HERB, G.;HARRIS, GEORGIANNA;MYERS, ROBERT, W.
发明人
BULL, HERB, G.;HARRIS, GEORGIANNA;MYERS, ROBERT, W.
