PROTECTIVE PROTEIN/CATHEPSIN A AND PRECURSOR: CRYSTALLIZATION, X-RAY DIFFRACTION, THREE-DIMENSIONAL STRUCTURE DETERMINATION AND RATIONAL DRUG DESIGN

摘要

The present invention provides crystallized protective protein/cathepsin A (PPCA), a precursor thereof (pPPCA) or at least one subdomain thereof; methods for x-ray diffraction analysis to provide x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design (RDD), based on using amino acid sequence data and/or x-ray crystallography data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms.