发明名称 |
COMPOSITIONS AND METHODS FOR BUCCAL DELIVERY OF PHARMACEUTICAL AGENTS |
摘要 |
A composition for transmucosally administering a drug to the oral cavity comprises an adhesive layer comprising a hydrophilic polymer having one surface adapted to contact a first tissue of the oral cavity and adhere thereto when wet and an opposing surface in contact with and adhering to an adjacent drug-containing layer comprising an effective amount of a drug and optionally an effective amount of a permeation enhancer, wherein the drugcontaining layer is adapted to contact and be in drug transfer relationship with a mucosal tissue of the oral cavity when the adhesive layer contacts and adheres to the first tissue. Preferred drugs include peptides, such as glucagon-like insulinotropic peptides. A method of transmucosally administering a drug to the oral cavity is also disclosed.
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申请公布号 |
CA2235402(A1) |
申请公布日期 |
1997.05.01 |
申请号 |
CA19962235402 |
申请日期 |
1996.10.22 |
申请人 |
THERATECH, INC. |
发明人 |
GUTNIAK, MARK K.;HEIBER, SONIA J.;EBERT, CHARLES D. |
分类号 |
A61K9/70;A61K9/00;A61K9/20;A61K31/00;A61K38/00;A61K38/11;A61K38/22;A61K38/23;A61K38/28;A61L15/00;A61P1/00;A61P1/02;(IPC1-7):A61K9/70 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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