HETEROTETRAMERIC COILED COIL STRUCTURES

摘要

A composition of matter as shown in the figure wherein: (a) I, II, III and IV are each alpha-helical polypeptides of about 21 to 35 residues; (b) moieties in positions a and d of helices I and IV are each independently amino acid residues; (c) moieties in positions b and c of helices I and III are each independently positively charged amino acid residues; (d) moieties in positions b and c of helices II and IV are each independently negatively charged amino acid residues; (e) moieties in positions e and g of helices I, II, III, and IV are each independently amino acid residues; and (f) moieties in positions f of helices I, II, III, and IV are each independently amino acid residues; and (g) each of I, II, III, and IV is optionally substituted at either or both of its termini with an effector domain or a specific ligand binding domain. Such a composition of matter is useful, among other things, for ligand-targeted drug delivery.