HUMAN EPITHELIAL ANTIGEN Ep-CAM DERIVED PEPTIDES AND THEIR USE

摘要

Peptides comprising an amino acid sequence which has the ability to bind to human Major Histocompatibility Complex (MHC) Class I molecules, in particular the MHC Class I allele HLA-A*0201, and especialy those peptides that are capable of inducing a primary cytotoxic T lymphocyte (CTL) response. The amino acid sequence is derived from the protein Ep-CAM. The peptides are useful for treatment or prophylaxis of Ep-CAM positive cells, in particular Ep-CAM associated cancers, for in vivo or in vitro induction of CTLs that are effective against Ep-CAM positive tumor cells, and for diagnostic purposes.