TREATING DISORDERS MEDIATED BY VASCULAR SMOOTH MUSCLE CELL PROLIFERATION

摘要

Disorders mediated by vascular smooth muscle proliferation are treated by administering a vascular smooth muscle antiproliferative effective amount of an I2 imidazoline receptor agonist. The disorders include atherosclerosis, risk of blockage of artery after coronary angioplasty or blood vessel injury from non-angioplasty cause, and proliferative diabetic retinopathy. I2 imidazoline receptor agonists include idazoxan, UK 14,304, naphazoline, cirazoline and agmatine.