Tricyclic compounds and intermediates thereof

摘要

Disclosed is a tricyclic compound represented by the formula (I): wherein each of R<1>, R<2>, R<3> and R<4> independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR<9>R<1><0>CO2R<1><1> (wherein each of R<9>, R<1><0> and R<1><1> independently represents hydrogen or C1-6 alkyl) or CONR<1><2>R<1><3> (wherein each of R<1><2> and R<1><3> independently represents hydrogen or C1-6 alkyl); R<5> represents hydrogen or C1-6 alkyl; each of R<6>, R<7> and R<8> independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y<1>-Y<2> represents CH2-O, CH2-S(O)n, (wherein n represents 0, 1, or 2), CH2CH2, CH=CH or CON(R<1><4>) (wherein R<1><4> represents hydrogen or C1-6 alkyl) and Z represents oxygen or sulfur, or a pharmaceutically acceptable salt thereof. The compound possesses an acyl coenzyme A: cholesterol acyltransferase-inhibiting activity, and thus are expected to have preventive and therapeutic effects on hyperlipemia and arteriosclerosis.