NOVEL METHOD FOR PREPARING TAXANE DERIVATIVES, NOVEL DERIVATIVES THUS OBTAINED AND COMPOSITIONS CONTAINING THEM.,申请号GR19960403091T-传众专利搜索

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发明名称	NOVEL METHOD FOR PREPARING TAXANE DERIVATIVES, NOVEL DERIVATIVES THUS OBTAINED AND COMPOSITIONS CONTAINING THEM.
摘要	<p>PCT No. PCT/FR93/01145 Sec. 371 Date May 23, 1995 Sec. 102(e) Date May 23, 1995 PCT Filed Nov. 22, 1993 PCT Pub. No. WO94/12484 PCT Pub. Date Jun. 9, 1994This invention relates to a method for the preparation of taxane derivatives having the formula (I) and pharmaceutical compositions which contain the derivatives thus obtained. In formula (I), R is hydrogen or acetyl, R1 is benzoyl or R2-O-CO wherein R2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl and Het is a 5-membered optionally substituted aromatic heterocycle (thiophene, tiazole, furan, pyrrole, imidazole, oxazole, isoxazole, pyrazole). The products of formula (I) have remarkable antitumor and antileukemia properties. <IMAGE> (I)</p>
申请公布号	GR3022359(T3)	申请公布日期	1997.04.30
申请号	GR19960403091T	申请日期	1997.01.23
申请人	RHONE-POULENC RORER S.A.	发明人	BOUCHARD, HERVE;BOURZAT, JEAN-DOMINIQUE;COMMERCON, ALAIN
分类号	C07D305/14;A61K31/335;A61K31/337;A61K31/34;A61K31/41;A61K31/415;A61K31/425;A61P35/00;A61P35/02;C07D405/12;C07D407/12;C07D409/12;C07D413/12;C07D417/12;(IPC1-7):C07D305/14	主分类号	C07D305/14
代理机构		代理人
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