DURCH REDUKTION ORTHOGONAL ENTFERNBARE HYDROXYLSCHUTZGRUPPEN UND IHRE VERWENDUNG IN DER CHEMISCHEN SYNTHESE VON OLIGONUKLEOTIDEN
摘要
<p>Hydroxyl-protecting groups orthogonally removable by reduction with a liquid reducing agent are disclosed. The novel hydroxyl-protecting groups are particularly useful in the chemical synthesis of linear and branched oligonucleotide structures, as they are readily removed from the protected molecule with mild reagents such as dithionite. Examples of such hydroxyl-protecting groups include the 2-methylene-9,10-anthraquinone (Maq) carbonate ester and the p-nitrobenzyl carbonate ester.</p>
申请公布号
DE69125380(D1)
申请公布日期
1997.04.30
申请号
DE1991625380
申请日期
1991.07.24
申请人
CHIRON CORP., EMERYVILLE, CALIF., US
发明人
URDEA, MICHAEL, S., ALAMO, CA 94507, US;HORN, THOMAS, BERKELEY, CA 94708, US