发明名称 |
NOVEL MACROCYCLIC LACTONES AND A PRODUCTIVE STRAIN THEREOF. |
摘要 |
<p>This invention provides the novel culture, Streptomyces hygroscopicus FERM BP-3688 and the macrocyclic lactones which were produced by the culture Streptomyces hygroscopicus (FERM BP-3688), Actinoplanes sp. (FERM BP-3832) or Streptomyces toyocaensis subsp.humicola (ATCC 39471) and an immunosuppressive agent, an antimycotic agent and an antitumor agent which comprises the said macrocyclic lactones. The macrocyclic lactones have formula (I) wherein R<1> is oxygen, two hydrogens or one hydrogen and one hydroxy; R<2>, R<3> and R<5> are each independently hydrogen, hydroxy or methoxy; and R<4> is hydroxy or hydrogen; provided that when R<1> is oxygen, R<4> is hydroxy and R<2> and R<5> are methoxy, R<3> is neither hydrogen nor methoxy.</p> |
申请公布号 |
GR3022309(T3) |
申请公布日期 |
1997.04.30 |
申请号 |
GR19970400070T |
申请日期 |
1997.01.16 |
申请人 |
PFIZER INC. |
发明人 |
NISHIDA, HIROYUKI;SAKAKIBARA, TATSUO;YAMAUCHI, YUJI;INAGAKI, TAISUKE;KOJIMA, YASUHIRO;KOJIMA, NAKAO |
分类号 |
A61K31/435;A61K31/445;A61P31/04;A61P35/00;A61P37/06;C07D498/18;C12N1/20;C12P17/18;C12R1/045;C12R1/465;(IPC1-7):C12P17/18 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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