发明名称 |
Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs |
摘要 |
The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the disclosure involve synthesis steps wherein a hydroxyl group on a sugar moiety to be added is blocked with a halo-substituted alkyl group during the process of adding it to an anthracycline ring compound.
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申请公布号 |
US5625043(A) |
申请公布日期 |
1997.04.29 |
申请号 |
US19950396290 |
申请日期 |
1995.02.27 |
申请人 |
PRIEBE, WALDEMAR;SKIBICKI, PIOTR;PEREZ-SOLER, ROMAN |
发明人 |
PRIEBE, WALDEMAR;SKIBICKI, PIOTR;PEREZ-SOLER, ROMAN |
分类号 |
C07H15/252;(IPC1-7):C07M15/24 |
主分类号 |
C07H15/252 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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