发明名称 |
Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (e-selectin) and LECAM-1 (l-selectin) |
摘要 |
Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical formulations in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.
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申请公布号 |
US5624909(A) |
申请公布日期 |
1997.04.29 |
申请号 |
US19950468888 |
申请日期 |
1995.06.06 |
申请人 |
GLYCOMED INCORPORATED |
发明人 |
RAO, NARASINGA;ANDERSON, MARK B.;NALEWAY, JOHN J.;MUSSER, JOHN H. |
分类号 |
G01N33/53;A61K31/704;A61K49/00;A61K51/00;A61K51/04;A61P29/00;C07H15/18;C07H15/203;C07H15/207;C07H15/24;C07H15/256;C07H17/04;C07J63/00;(IPC1-7):A01N37/00;A01N39/00;A61K31/00;A61K31/56 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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