1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds

摘要

PCT No. PCT/JP94/00787 Sec. 371 Date Nov. 14, 1995 Sec. 102(e) Date Nov. 14, 1995 PCT Filed May 16, 1994 PCT Pub. No. WO94/27973 PCT Pub. Date Dec. 8, 19941-(2-benzimidazolyl)-1,5-diazacyclooctane compounds represented by the formula: <IMAGE> wherein X represents a hydrogen atom or a halogen atom; Y represents a covalent bond, a straight- or branched-chain alkylene group having 1 to 6 carbon atoms, or a straight- or branched-chain alkenylene group having 2 to 6 carbon atoms; R represents a hydrogen atom, or a straight- or branched-chain alkyl group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The compounds represented above are novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.