NOVEL BENZOTHIAZOLE DERIVATIVES AND PROCESS FOR PREPARING THE SAME

摘要

The benzothiazole derivative of general formula and its enantiomer is prepared as follows: (1) A compound of general formula(VI) is replaced by a halogen and is reacted with alkyl or acylhalide under alkali condition to obtain a compound of general formula(VII). (2) After halogen-lithium replacement reaction of a compound(VII), a compound of general formula(VIII) is obtained by reacting with dimethyl oxalate. (3) And then an intermediate of general formula(i) is produced by reacting a compound of general formula(VIII) with methoxyl amine under basic condition or wittig reaction with phosphorous ylide. A benzothiazole is used for eliminating botanical germs or animal fungus. In the above formula, R1, R2 and R3 is independent hydrogen, halogen atom and like respectively. X is nitrogen or hydrocarbon.