发明名称 |
METHOD FOR RESTORING GLUCOSE RESPONSIVENESS TO INSULIN SECRETION |
摘要 |
This invention comprises engineered cells that express a nucleic acid that encodes a calbindin molecule, and exhibit the ability to secrete insulin in a glucose-sensitive fashion. This invention also comprises an artificial tissue that, when implanted into recipients that do not secrete insulin in a glucose-sensitive fashion, imparts to the recipients the ability to secrete insulin in a glucose-sensitive fashion. The artificial tissue comprises engineered cells that express a nucleic acid that encodes a calbindin molecule and secrete insulin in a glucose-sensitive fashion, enclosed by a semipermeable porous matrix.
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申请公布号 |
WO9714441(A1) |
申请公布日期 |
1997.04.24 |
申请号 |
WO1996US16736 |
申请日期 |
1996.10.17 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;POLLOCK, ALLAN, S.;CHRISTAKOS, SYLVIA;REDDY, DAPHNE |
发明人 |
POLLOCK, ALLAN, S.;CHRISTAKOS, SYLVIA;REDDY, DAPHNE |
分类号 |
A61K35/12;A61K38/00;A61K48/00;C07K14/47;C12N5/071;(IPC1-7):A61K48/00;C12N5/00;C12N15/00 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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