Stabilisierter Varizella-Lebendimpfstoff

摘要

Disclosed is a stabilized live vaccine containing a varicella virus and a stabilizer, wherein the vaccine is substantially free of Ca<2><+> ions and Mg<2><+> ions. This stabilized live vaccine is extremely excellent in storage stability and heat resistance. Also disclosed is an improved stabilizer for a live varicella vaccine, comprising at least one member selected from gelatin and hydrolyzed gelatin, each being substantially free of Ca<2><+> ions and Mg<2><+> ions. The stabilizer can advantageously be used to stabilize a live vaccine containing a varicella virus. The substantial freedom of Ca<2><+> ions and Mg<2><+> ions can be attained by masking Ca<2><+> ions and Mg<2><+> ions present in a live vaccine containing a varicella virus and a stabilizer, with a chelating reagent, or by using as a stabilizer gelatin and/or a gelatin derivative after being purified to remove Ca<2><+> ions and/or Mg<2><+> ions contained therein.