SYNTHESIS OF POLYMERISABLE PHOSPHODIESTERS

摘要

A mono- or di-functional phosphoramidite phosphitylating agent is used to phosphitylate an ethylenically unsaturated alcohol. The product may be oxidised to form the corresponding phosphate ester which may be reacted in further steps to form phosphoryl choline derivatives. The process is of value in the synthesis of 2-(Methacryloyloxyethyl)-2'- (trimethylammoniumethyl)phosphate, inner salt. It has the advantage over prior art processes in that the starting materials and intermediates are more stable and consequently easier to handle.