A heparin complex and medical device having such substance

摘要

A heparin complex having anticoagulation activity and being insoluble in blood is provided. The preferred complex comprises a cationic alkyldimethylammonium represented by formula (1): <CHEM> wherein R<1> and R<2> are independently an alkyl or alkenyl group, each group is C12-C24 when R<1> and R<2> are the same, the sum of the carbon atoms are 26-38 when R<1> and R<2> are different; and heparin. In this complex, reduction in the anticoagulation activity of the heparin by the formation of the complex is minimized, and ionic bonding of the heparin is quite stable. Dissolution of the cationic alkyldimethylammonium from the coating is also minimized. A medical device coated with such substance is also provided.